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Despite their small size, they have immense biological significance in molecular biology: peptides function as a peptide hormone like PPY, enzymes, neurotransmitters, and signal molecules that mediate immune responses, cell signaling, tissue repair, and metabolic regulation

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Several synthetic routes for NDGA have been reported, with one of the latest involving Ti-induced carbonyl coupling, which yields NDGA and its stereoisomer in high quantities (Gezginci and Timmermann 2001)